The OrganOx® technology has been in development for over 20 years and has been extensively peer-reviewed. There are over 30 journal publications supporting the patented OrganOx technology for normothermic organ preservation and repair prior to transplantation, and demonstrating its numerous benefits over conventional cold storage and cold perfusion technologies:
1. Ravikumar R, Jassem W, Mergental H, Heaton N, Mirza D, Perera MTPR, Quaglia A, Holroyd D, Vogel T, Coussios CC, Friend PJ. Am J Transplant 2016; 16:1779-1787. Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
2. Angelico R, Perera T, Ravikumar R, Nasralla D, Mergental H, Isaac J, Roll G, Ferraz-Neto BH, Iqbal A, Cilliers H, Vasanth S, Muiesan P, Friend P, Mirza D - ESOT (2015); abstract no. B0132. Normothermic machine perfusion of cadaveric liver grafts is associated with improved post-reperfusion haemodynamics.
3. Nasralla D, Weissenbacher A, Mergental H, Jassem W, Coussios C, Friend P - ESOT (2015); abstract no. LB009. Surgical experience with normothermic machine perfusion in human liver transplantation.
4. Ploeg R and Friend P - Transplant International (2015) 28: 633. New strategies in organ preservation: Current and future role of machine perfusion in organ transplantation.
5. Ravikumar R, Leuvenink H, Friend P - Transplant International (2015) 28: 690-699. Normothermic liver preservation: a new paradigm?
6. Waldman JP, Vogel T, Burlak C, Coussios C, Dominguez J, Friend P, Rees MA - Xenotransplantation (2013) 20(4) 239-251. Blocking porcine sialoadhesin improves extracorporeal porcine liver xenotransplantation with human blood.
7. T. Vogel, J.G. Brockmann, C.-C. Coussios and P.J. Friend - Transplantation Reviews (2012) 26:156-162. The Role of Normothermic Extracorporeal Perfusion in Minimizing Ischemia Reperfusion Injury.
8. Jamieson RW, Zilvetti M, Roy D, Hughes D, Morovat A, Coussios CC, Friend PJ. – Transplantation (2011) 92 289-295. Hepatic steatosis and nortmothermic perfusion: preliminary experiments in a porcine model.
9. T. Vogel, J.G. Brockmann, C. C. Coussios and P.J. Friend - in “Methods in Bioengineering Series Organ Preservation and Re-Engineering”, edited by K Yugun and C Lee, Elsevier Special Series on Biotechnology. Normothermic Machine Perfusion of the Liver 1-20.
10. Vogel T, Brockmann JG and Friend PJ – Current Opinions in Organ Transplantation (2010) 15 167-72 Ex-vivo normothermic liver perfusion: an update.
11. Brockmann J, Reddy S, Coussios C, Pigott D, Guerriero D, Hughes D, Morovat A, Roy D, Winter L and Friend PJ – Annals of Surgery (2009) 250(1) 1-6. Normothermic perfusion – a new paradigm for organ preservation.
12. Reddy SP, Brockmann J and Friend PJ – Transplantation (2009) 87 631-2 Normothermic perfusion: a mini review.
13. Jamieson RW and Friend PJ – Frontiers in Bioscience (2008) 13 221-225. Organ reperfusion and preservation.
14. Jamieson RW and Friend PJ – Transplantation Reviews (2006) 20 172-178. Normothermic organ preservation.
15. Reddy S and Friend PJ – Current Opinions in Organ Transplantation (2005) 10 95-100. Liver transplantation outcomes using donors after cardiac death.
16. Reddy S, Greenwood J, Maniakin N, Bhattacharjya S, Zivetti M, Brockmann J, James T, Piggott D and Friend PJ – Liver Transplantation (2005) 11 35-38. Non-heart-beating donor porcine livers: the adverse effect of cooling.
17. Rees MA, Butler AJ, Brons GM, Negus MC, Skepper JN and Friend PJ – Xenotransplantation (2005) 12 13-19. Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization.
18. Rees MA, Butler AJ, Negus MC, Davies HSF and Friend PJ – Transplantation (2004) 77 1416-1423. Classical pathway complement destruction is not responsible for the loss of human erythrocytes during porcine liver perfusion.
19. Reddy SP, Bhattacharjya S, Maniakin N, Greenwood J, Guerreiro D, Hughes D, Imber CJ, Piggott DW, Fuggle S, Taylor R and Friend PJ – Transplantation (2004) 77 1328-1332. Preservation of porcine non-heart-beating donor livers by sequential cold storage and warm perfusion.
20. Reddy S, Zivetti M, Brockmann J, McClaren A and Friend PJ – Liver Transplantation (2004) 10 1223-1232. Liver transplantation from non-heart beating donors: Current status and future prospects.
21. McLaren AJ and Friend PJ – Transplantation International (2003) 16 701-708. Trends in organ preservation.
22. St. Peter SD, Imber CJ, Kay J, James T and Friend PJ – Transplantation Proceedings (2003) 35 1587-1590. Hepatic control of perfusate homeostasis during normothermic extracoropreal preservation.
23. Imber CJ, St Peter SD, Handa A and Friend PJ – Liver Transplantation (2002) 8 415-423.
24. St. Peter SD, Imber CJ and Friend PJ – Lancet (2002) 359 604-613. Liver and kidney preservation by perfusion.
25. Imber CJ, St. Peter SD, Lopez I, Lemonde H, Rees M, Butler A, Clayton PT and Friend PJ – American Journal of Transplantation (2002) 2 593-599. Optimisation of bile production during normothermic preservation of porcine livers.
26. Rees Ma, Butler AJ, Davies HSF, Bolton E, Wight DGD, Skepper J, White DJG and Friend PJ – Transplantation (2002) 73 1460-1467. Porcine livers perfused with human blood mount a graft-versus-host reaction.
27. Rees MA, Butler AJ, Chavaz-Cartaya G, Wight DGD, Casey ND, Alexander G, Khuder SA, White DJG and Friend PJ – Transplantation (2002) 73 1194-2002. Prolonged function of extracorporeal hDAF transgenic pig livers perfused with human blood.
28. Butler AJ, Rees MA, Wight DGD, Casey ND, Alexander G, White DJG and Friend PJ – Transplantation (2002) 73 1212-1218. Successful extracorporeal porcine liver perfusion for 72 hours.
29. St. Peter SD, Imber CJ, Lopez I, Hughes D and Friend PJ – British Journal of Surgery (2002) 89 609-616. Extended preservation of non-heart beating donor livers with normothermic machine perfusion.
30. Imber CJ, St Peter SD, Lopez I, Pigott D, James T, Taylor R, McGuire J, Hughes D, Butler A, Rees M and Friend PJ – Transplantation (2002) 73 701-709. Advantages of normothermic perfusion over cold storage in liver preservation.
31. St Peter SD, Imber CJ, Lopez I, McGuire J, James T, Taylor R and Friend PJ –Liver Transplantation (2002) 8 21-26. β-galactosidase as a marker of ischaemic injury and a mechanism for viability assessment in porcine liver transplantation.
32. Imber CJ, St Peter SD, Lopez I, Guiver L and Friend PJ – Liver transplantation (2002) 8 545-549. Current practice regarding the use of fatty livers: A transatlantic survey.
33. St Peter SD, Imber CJ, Lopez I, McGuire J, James T, Taylor R, D Pigott and Friend PJ – Transplantation proceedings (2001) 33 3753-3755. β-galactosidase as a novel marker of ischaemic injury and a mechanism for viability assessment in liver transplantation.
34. Friend PJ, Imber CJ, St. Peter SD, Lopez I, Butler AJ and Rees MA – Transplantation Proceedings (2001) 33 3436-3438. Normothermic perfusion of the isolated liver.
35. Imber CJ, St Peter SD, Lopez I, and Friend PJ – Transplantation Proceedings (2001) 33 3718-3719. Use of laser Doppler as a non-invasive measure of ischaemia reperfusion injury in the pig liver.