Current cold transplantation technologies have reached their limit, with little innovation for decades and flat or declining liver transplant numbers in both the US and Europe. Based on more than 15 years of pre-clinical research, the OrganOx® technology has been developed by transplant surgeons and engineers to address this major unmet need and revolutionize organ preservation.
Rather than being cooled to ice temperature to slow down their metabolism, organs are being kept alive under physiological conditions at normal body temperature in a functional state throughout the preservation period. This major development has been made possible by OrganOx's patented autoregulation technology, which has been extensively peer-reviewed and validated in more than 30 journal publications.
The OrganOx technology is designed to create a body-mimicking environment around the liver, providing oxygen and nutrition at physiological flow rates and normal body temperature.
As illustrated above, a normothermic suspension of red cells in colloid solution is used to perfuse the organs. The perfusate is pumped out of the inferior vena cava using a centrifugal pump, oxygenated and heated through a membrane oxygenator, before diverting part of the flow into the hepatic artery at physiological arterial pressure and the rest to the soft-shell resevoir; the portal vein is gravity-fed from the reservoir. Flows and pressures are continuously monitored, and OrganOx's patented autoregulation technology ensures that blood is never forced through the organ, enabling it to choose its own blood supply.
The use of in-line blood gas analysis further ensures fully automated monitoring and control of pO2 and pCO2 levels, facilitating maintenance of acid-base homeostasis. Last but not least, continous infusion of heparin, prostacyclin, bile salts and nutrition ensure good vasodilation, protection against coagulation, and the provision of an environment that enables near-physiological metabolic and synthetic liver function. Continous monitoring of haemodynamic, synthetic and metabolic parameters provides the clinician with additional information prior to transplant as to the function and viability of the organ in a a normothermic environment.