OrganOx metra®

The World’s First Normothermic Machine Perfusion (NMP) Platform

This Changes Everything.

OrganOx metra normothermic machine perfusion (NMP) device for liver transplant procedures.

OrganOx metra® has already changed transplantation for the liver.¹

Now, it’s the foundation of a platform that aims to transform the entire field of organ technology.

Every Organ is a Life-Saving Opportunity

The OrganOx metra platform extends organ preservation time,² giving clinicians a longer window and more options to make better use of donor pools. Extending the length of time an organ is perfused enables clinicians to perform a more in-depth functional assessment on it, which can help lead to better outcomes.

OrganOx metra can help

Lower organ discard rates^3,4

Close-up of two hands gently holding each other, symbolizing care and support in a healthcare setting.

Make more organs available for transplant^3,4

Three women smiling and sitting on grass in warm afternoon light, representing the community of patients, families, and care teams in the organ transplant journey.

Shorten transplant wait lists⁵

Smiling couple embracing in front of a weathered brick wall, representing the joy and connection experienced by patients and loved ones throughout the organ transplant journey.

Enable better planning for safer surgeries⁶

Transplant surgical team in scrubs and masks operating under bright surgical lights in a modern operating room.

More Time. More Options. More Hope.

OrganOx metra can provide transplant teams with the time they need to confidently make individual decisions for each organ and recipient, along with the flexibility to perform surgery when all involved are best prepared for success. OrganOx metra is built on NMP technology that has been shown by clinical evidence to support better outcomes.

Increases overall transplant volume by 20%⁵

Allows surgeries to be planned and pre-scheduled instead of urgent procedures

Enables surgeons to more confidently assess and accept more marginal organs^3,4

Reduces discard rates up to 50% vs. static cold storage⁷

Lowers graft injury by 50% (as measured by hepatocellular enzyme release)⁷

Empowers transplant centers with more clinical oversight, participation, and control throughout the entire workflow

OrganOx metra for Liver

With its multiple advanced automation features, our flagship product maintains perfusion conditions with an ease, consistency, and predictability that frees transplant surgeons to focus on the surgery itself.

How It Works

With the OrganOx metra, the donor liver is continuously perfused with oxygenated blood-based perfusate, medications, and nutrients at normal body temperature and near-physiological pressures and flows. Keeping the liver functional throughout preservation enables a more informed and accurate assessment of its viability for transplant.

Centrifugal Pump

A centrifugal pump draws blood from the liver, intelligently adjusting to physiological changes to ensure optimal perfusion.

Oxygenator

A self-regulating oxygenator receives oxygen that has been concentrated from ambient air, which it transfers into the blood-based perfusate while it is warmed by an on-board heater.

Perfusate Reservoir

A soft-shell reservoir stores the warm, oxygenated blood-based perfusate and supplies it to the liver under near-physiological pressure.

Blood Gas Analyzer

In-line blood gas analysis provides real-time monitoring of pO2, pCO2, pH and temperature.

Medication Infusion Driver

A syringe infusion driver delivers insulin, heparin, bile salts and epoprostenol. Infusions are delivered automatically, at a fixed rate, to provide continuous infusion throughout and help minimize the operator’s hands-on time.

Nutrition Pump

A mini roller pump can deliver a nutrition solution, or TPN, in response to user-measured glucose values.

Touchscreen

An easy-to-use touchscreen provides real-time pO2, pCO2, pH values and other perfusion information at a glance throughout the procedure.

From Our Newsroom

Keep up to date with the latest OrganOx updates and recent news in organ transplantation.

News

Terumo to acquire OrganOx Limited, a leading innovator in organ preservation devices, marking strategic entry into the organ transplantation-related sector

News

OrganOx Announces Second Private Placement Closing, Investments by Intuitive Ventures and Terumo Ventures

Press Release

eGenesis and OrganOx Announce U.S. FDA Clearance of IND Application for the Treatment of Patients with Acute-On-Chronic Liver Failure

Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., & Friend, P. J. (2016). Liver transplantation after ex vivo normothermic machine preservation: A phase 1 (first-in-man) clinical trial. American Journal of Transplantation, 16(6), 1779–1787. https://pubmed.ncbi.nlm.nih.gov/26752191/.

OrganOx Ltd. (2024). OrganOx® metra® instructions for use (USA version, Rev05). OrganOx Ltd. https://sites.google.com/view/2tyshpvxatbpbjgs7bff6bs7nturpw/na-ifu?authuser=0

Mergental, H., Laing, R. W., Kirkham, A. J., Perera, M. T. P. R., Boteon, Y. L., Attard, J., Barton, D., Curbishley, S., Wilkhu, M., Neil, D. A. H., Hübscher, S. G., Muiesan, P., Isaac, J. R., Roberts, K. J., Abradelo, M., Schlegel, A., Ferguson, J., Cilliers, H., Bion, J., Adams, D. H., … Mirza, D. F. (2020). Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nature communications, 11(1), 2939. https://doi.org/10.1038/s41467-020-16251-3

Olumba, F. C., Zhou, F., Park, Y., Chapman, W. C., & RESTORE Investigators Group (2023). Normothermic Machine Perfusion for Declined Livers: A Strategy to Rescue Marginal Livers for Transplantation. Journal of the American College of Surgeons, 236(4), 614–625. https://doi.org/10.1097/XCS.0000000000000555

Wehrle, C. J., Hong, H., Gross, A., Liu, Q., Ali, K., Cazzaniga, B., Miyazaki, Y., Tuul, M., Modaresi Esfeh, J., Khalil, M., Pita, A., Fernandes, E., Kim, J., Diago-Uso, T., Aucejo, F., Kwon, D. C. H., Fujiki, M., Quintini, C., Schlegel, A., Pinna, A., … Hashimoto, K. (2024). The impact of normothermic machine perfusion and acuity circles on waitlist time, mortality, and cost in liver transplantation: A multicenter experience. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 10.1097/LVT.0000000000000412. Advance online publication. https://doi.org/10.1097/LVT.0000000000000412.

Wehrle, C. J., Zhang, M., Khalil, M., Pita, A., Modaresi Esfeh, J., Diago-Uso, T., Kim, J., Aucejo, F., Kwon, D. C. H., Ali, K., Cazzaniga, B., Miyazaki, Y., Liu, Q., Fares, S., Hong, H., Tuul, M., Jiao, C., Sun, K., Fairchild, R. L., Quintini, C., … Schlegel, A. (2024). Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis. Annals of surgery, 280(2), 300–310. https://doi.org/10.1097/SLA.0000000000006291

Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., Heaton, N., Imber, C., Jassem, W., Jochmans, I., Karani, J., Knight, S. R., Kocabayoglu, P., Malagò, M., Mirza, D., Morris, P. J., Pallan, A., … Consortium for Organ Preservation in Europe (2018). A randomized trial of normothermic preservation in liver transplantation. Nature, 557(7703), 50–56. https://doi.org/10.1038/s41586-018-0047-9