Evidence-based improvements in liver transplantation outcomes

Bral M, Dajani K, Leon Izquierdo D et al. Liver Transpl. 2019;25:848–58.

A nonrandomised pilot study assessing whether the OrganOx metra can be used with a back-to-base model without impacting patient outcomes.

Manzia TM, Toti L, Quaranta C, et al. Int J Surg Rep. 2019;57:163–6.

This case report details how functional assessment of a nonagenarian liver with the OrganOx metra resulted in successful transplantation.

Reddy S, Zivetti M, Brockmann J, McClaren A and Friend PJ – Liver Transplantation (2019) 10 1223-1232.

Ceresa CDL, Nasralla D, Watson CJE, et al. Liver Transpl. 2019; [Epub ahead of print].

This multi-centre prospective study included 31 livers for transplantation and demonstrated that the OrganOx metra could be successfully used to extend the preservation of donor livers after a period of static cold storage without impacting patient outcomes.

Nasralla D, Coussios CC, Mergental H, et al. Consortium for Organ Preservation in Europe. Nature. 2018;557(7703):50–56.

The first randomised controlled trial comparing machine perfusion technology with static cold storage in human liver transplantation. In this trial, the OrganOx metra was transported to and from the donor centre to minimise cold storage time.

Compared with static cold storage, the OrganOx metra achieved a 50% lower level of graft injury despite a 50% lower rate of organ discard and a 54% longer mean preservation time.