OrganOx metra enhances current clinical understanding of donor liver function leading to more donor livers being available for transplantation1

Assessment of donor liver function is limited with static cold storage and over a third of deceased donors in the UK do not result in a transplanted liver.1–3 The OrganOx metra enables the assessment of donor liver function by allowing surgeons to monitor markers such as perfusate lactate clearance, pH, transaminase levels, glucose metabolism and bile pH during preservation.2,3 Informed decisions on donor liver function may lead to fewer discarded organs and increased utilisation, as demonstrated in our randomised trial.1

Normothermic machine perfusion with the metra has been shown to reduce the risk and impact of ischaemic reperfusion injury and graft injury following transplant.1

The risks of graft injury during static cold storage are well established in marginal donor organs such as DCD (donation after circulatory death) or elderly donors.5–7

Compared to static cold storage, the metra has been associated with a 50% reduction in graft injury, as measured by a 50% reduction in peak AST during the 7 days after liver transplantation. This was despite a 54% increase in preservation time.1

Preservation times and Peak AST

  NMP SCS P value
Mean peak AST (95% CI) 488
(409–583)
965
(795–1172)
<0.001
Total preservation time 11h 54min 7h 45min <0.001

Adapted from Nasralla D et al. Nature 2018; 557(7703):50–56

49% reduction in peak AST between NMP and SCS despite a 54% longer mean preservation time

Improve transplant logistics with the metra

metra and transplant logistics

Longer preservation times with the metra facilitate complex and lengthy transplant surgeries

metra and complex surgeries

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References: 1. Nasralla D et al. Nature 2018; 557(7703):50–56. 2. Laing RW et al. BMJ Open 2017;7:e017733. 3. NHS Blood and Transplant. Organ Donation and Transplantation Activity Report 2017/18. 4. Jayant K et al. Exp Rev Gastroenterol Hepatol 2018;12:1045–1058. 5. Manara AM et al. BJA 2012;108 (suppl 1):i108–i121. 6. Zhai Y et al. Nat Rev Gastroenterol Hepatol. 2013;10(2):79–89. 7. Boteon YL et al. Current Transplantation Reports 2018;5:113–120.