METRA AND TRANSPLANT LOGISTICS
More time, less urgency with up to 24 hours† of organ preservation
The OrganOx metra® allows transplant centres up to 24 hours† preservation time to plan and prepare for every liver transplant1–4
The preservation time of donor livers in static cold storage is limited.9 By extending donor liver preservation to up to 24 hours†, the metra enables more flexibility in the timing of liver transplant surgery, reducing the urgency to transplant donor livers and supporting improved operating theatre planning.1–4 In a clinical trial, 84% of transplant surgeries took place during the day with the metra compared to 65% using static cold storage.4
Daylight transplant procedures
Adapted from Bral M et al. Liver Transpl 2019; 25(6):848–858
84% of transplants took place during the day versus 65% with static cold storage
Maximise transplant logistics with the metra
The metra can be used in two ways: transport mode1 (continuous NMP) or “back to base” mode (NMP following static cold storage)4,5 offering transplant centres maximum flexibility of use.
More time, less urgency and up to 24 hours† of organ preservation without compromising outcomes.1–4 The metra significantly reduces the risk of early allograft dysfunction in deceased donor livers compared to static cold storage.1
Early allograft dysfunction in deceased donor livers is associated with an increased risk of graft loss, additional surgeries and patient mortality.6–8
In a randomised trial, compared to static cold storage, the metra reduced early allograft dysfunction by 74%, while peak serum AST levels, a predictive biomarker for graft and patient survival, were 49% and 73% lower during the first 7 days after transplantation for all transplanted livers and transplanted DCD (donation after circulatory death) livers, respectively.1
Donor type and primary outcomes
| Donation after brain death, DBD (n=167) | ||||
|---|---|---|---|---|
| NMP (n=87) |
SCS (n=80) |
Difference (%) |
P value | |
| Mean peak AST (96% CI) | 526 (427–648) |
880 (709–1094) |
354 (40%) |
<0.001 |
| Donation after circulatory death, DCD (n=55) | ||||
| NMP (n=34) |
SCS (n=21) |
Difference (%) |
P value | |
| Mean peak AST (95% CI) | 390 (278–546) |
1458 (945–2251) |
1068 (73%) |
<0.001 |
Adapted from Nasralla D et al. Nature 2018; 557(7703):50–56
The metra reduced peak AST by 49% and 73% for all transplanted livers and transplanted DCD livers respectively
Longer preservation times with the metra facilitate complex and lengthy transplant surgeries
metra and complex surgeries
Explore functional assessments of donor livers with the OrganOx metra
metra and functional liver assessment
Want to know more about the metra?
If you would like to know more about the metra and how it may benefit your liver transplantation unit, click ‘Contact Us’ and a member of the OrganOx team will be in touch.
References: 1. Nasralla D et al. Nature 2018; 557(7703):50–56. 2. Mergental H et al. Hepatology 2018; 68(1):(Suppl). 3. NICE Interventional procedures guidance (IPG636). Available at: https://www.nice.org.uk/guidance/ipg636. 4. Bral M et al. Liver Transpl 2019; 25(6):848–858. 5. Ceresa CDL et al. Liver Transpl 2019; 25(10):1503-1513. 6. Olthoff KM et al. Liver Transpl. 2010;16:943–949. 7. Bastos-Neves D et al. Hepatobiliary Pancreat Dis Int 2019; [Epub ahead of print]. 8. Brea-Gomez E et al. Transplant Proc 2018;50:605–609. 9. Feng et al American Journal of Transplantation 2006; 6: 783–790.
UK/US MD-040-11-1 - September 2022